Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout | Semantic Scholar (2025)

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@article{Pineda2015AnimalMO, title={Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout}, author={Carlos Pineda and Arturo Javier Fuentes-G{\'o}mez and Cristina Hern{\'a}ndez-D{\'i}az and Yessica Zamudio-Cuevas and Javier Fern{\'a}ndez-Torres and Ambar L{\'o}pez-Macay and I Alba-S{\'a}nchez and Javier Camacho-Galindo and Lucio Ventura and Luis Enrique G{\'o}mez-Quiroz and Mar{\'i}a Concepci{\'o}n Guti{\'e}rrez-Ru{\'i}z and Francisco J. Garc{\'i}a-v{\'a}zquez and Anthony M Reginato and Marwin Gutierrez and Alberto Gabriel L{\'o}pez-Reyes}, journal={Arthritis Research \& Therapy}, year={2015}, volume={17}, url={https://api.semanticscholar.org/CorpusID:8130059}}
  • C. Pineda, A. J. Fuentes-Gómez, A. López-Reyes
  • Published in 26 February 2015
  • Medicine

The rabbit model of MSU crystal-induced acute arthritis efficiently reproduces the inflammatory, US, SF and histopathological changes of the human acute gouty attack.

35 Citations

Highly Influential Citations

3

Background Citations

16

Methods Citations

2

Results Citations

2

35 Citations

Minimally Invasive Embedding of Saturated MSU Induces Persistent Gouty Arthritis in Modified Rat Model
    HanLin XuShengping LiX. XueZiyi ChenY. Hua

    Medicine

    BioMed research international

  • 2021

A minimally invasive method was developed to establish modified rat model of intra-articular MSU deposition and this model was proved to be a simple reproducible method to mimic the pathological characteristics of persistent gouty arthritis.

New animal model of chronic gout reproduces pathological features of the disease in humans
    Jiwei WangPeiqi Hao Tianrui Xu

    Medicine

    RMD Open

  • 2023

The authors' model more accurately replicates the pathological features of gouty arthritis compared with gout induced by MSU crystal injections, making it particularly suitable for further investigations into the pathogenesis of gouts and also serves as a valuable platform for screening potential antigout agents.

  • PDF
A Novel Rat Model of Persistent Gouty Arthritis by Minimally Invasive Saturated Msu Embedding
    HanLin XuShengkun LiX. XueZiyi ChenY. Hua

    Medicine

  • 2020

This model was proved to be a simple reproducible method to mimic the pathological characteristics of intra-articular crystal arthritis and suggested that the frequencies of MSU interventions promoted expression of proinflammatory factors.

  • PDF
Validation of Musculoskeletal Ultrasound in the Assessment of Experimental Gout Synovitis.
    E. NaredoJ. P. MedinaS. Pérez-BaosA. MedieroG. Herrero-BeaumontR. Largo

    Medicine

  • 2018
  • 6
Gout‐associated uric acid crystals induce tophi ulcerations and impair wound healing in a novel gouty ulcer model
    W. BaoYi Xue C. Jia

    Medicine, Environmental Science

    Wound repair and regeneration : official…

  • 2021

A novel gouty ulcer rat model was constructed, which also revealed the existence of persistent chronic inflammation, and MSU crystals were subcutaneously injected into the back of rats to simulate tophi formation and ulceration.

  • 6
MSC therapy ameliorates experimental gouty arthritis hinting an early COX-2 induction
    J. P. MedinaIsmael Bermejo-Álvarez R. Largo

    Medicine

    Frontiers in immunology

  • 2023

In vivo and in vitro results showed that a single systemic dose of Ad-MSC decrease the intensity and duration of the inflammatory response by an early local COX-2 upregulation and PGE2 release, and could be considered as a pharmacological alternative in patients with comorbidities that preclude conventional treatment.

Case Report: Articular Gout in Four Dogs and One Cat
    Hyosung KimHyun-Jeong HwangHan-Jun KimS. Do

    Medicine

    Frontiers in Veterinary Science

  • 2022

The first report to confirm that articular gout can occur in dogs and cats is reported, confirmed by polarized microscopy.

  • PDF
Combined effects of MSU crystals injection and high fat-diet feeding on the establishment of a gout model in C57BL/6 mice
    Xiaoying LinTiejuan ShaoXianghui WenMingzhu WangChengping WenZhixing He

    Medicine

    Advances in Rheumatology

  • 2020

Compared to hyperuricaemia model or acute gouts model, the compound gout model showed little advantages of elevating serum uric acid, causing foot swelling and gout inflammation, while it caused more severe serum inflammation and gut microbiota dysbiosis.

  • 17
  • PDF
Performance of Ultrasound in the Clinical Evaluation of Gout and Hyperuricemia
    Ling CaoTianyi Zhao Xiaoxia Zhu

    Medicine

    Journal of immunology research

  • 2021

HAG is an early performance of MSU crystal deposition in joints of gout and HUA, and early urate-lowering therapy (ULT) should be considered in patients with gout, DCS, or tophi.

Better understanding of acute gouty attack using CT perfusion in a rabbit model
    Yabin HuQing Yang Mi Yan

    Medicine

    European Radiology

  • 2018

Following injection of MSU crystals, producing an acute gouty attack, CTP successfully assessed hemodynamic changes and the ascending rate of MVD was the highest among that of all parameters; so was the descending rate of CL.

  • 3

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51 References

The inflammatory process of gout and its treatment
    B. CronsteinR. Terkeltaub

    Medicine

  • 2006

There are no placebo-controlled, randomized clinical studies for any of the therapies commonly used, although comparative studies have demonstrated that many nonsteroidal anti-inflammatory drugs are equivalent to indomethacin with respect to controlling acute gouty attacks.

  • 206
  • PDF
Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis
    R. TorresL. Macdonald A. Murphy

    Medicine

    Annals of the rheumatic diseases

  • 2009

IL1 inhibition both prevented and relieved pain and ankle joint inflammation in response to intra-articular MSU crystals in mice, suggesting that IL1 Trap has the potential to both prevent and treat gouty arthritis.

  • 150
  • PDF
Hyaline cartilage involvement in patients with gout and calcium pyrophosphate deposition disease. An ultrasound study.
    E. FilippucciM. GutierrezD. GeorgescuF. SalaffiW. Grassi

    Medicine

    Osteoarthritis and cartilage

  • 2009
  • 205
  • PDF
Gout. Imaging of gout: findings and utility
    F. Pérez-RuizN. DalbethA. UrresolaE. de MiguelN. Schlesinger

    Medicine

  • 2009

In clinical practice they may be considered mainly for evaluating the presence and extent of crystal deposition, and structural changes that may impair function or functional outcomes, and also to monitor the response to urate-lowering therapy.

  • 112
  • PDF
Joint and tendon subclinical involvement suggestive of gouty arthritis in asymptomatic hyperuricemia: an ultrasound controlled study
    C. PinedaL. Amezcua-Guerra M. Gutierrez

    Medicine

  • 2011

These data demonstrate that morphostructural changes suggestive of gouty arthritis induced by chronic hyperuricemia frequently occur in both intra- and extra-articular structures of clinically asymptomatic individuals.

  • 229
  • PDF
Crystal-associated synovitis- ultrasonographic feature and clinical correlation.
    D. FodorA. AlbuC. Gherman

    Medicine

    Ortopedia, traumatologia, rehabilitacja

  • 2008

The aim of this paper is to describe the ultrasonographic findings in rheumatologic pathology due to crystal deposition. There are four main types of crystals involved: monosodium urate, calcium

  • 33
"Crystal clear"-sonographic assessment of gout and calcium pyrophosphate deposition disease.
    W. GrassiG. MeenaghE. PascualE. Filippucci

    Medicine

    Seminars in arthritis and rheumatism

  • 2006
  • 220
  • Highly Influential
Ultrasound-detected musculoskeletal urate crystal deposition: which joints and what findings should be assessed for diagnosing gout?
    E. NaredoJ. Uson E. Pascual

    Medicine

    Annals of the rheumatic diseases

  • 2014

The results suggest that US bilateral assessment of one joint, three articular cartilages and two tendons may be valid for diagnosing gout with acceptable sensitivity and specificity.

  • 169
  • Highly Influential
Attenuation of monosodium urate crystal‐induced arthritis in rabbits by a neutralizing antibody against interleukin‐8
    A. NishimuraT. Akahoshi K. Matsushima

    Medicine

    Journal of leukocyte biology

  • 1997

The intraarticular injection of a neutralizing anti‐IL‐8 antibody significantly attenuated the crystal‐induced joint swelling that occurred at 12 h, and neutrophil infiltration into arthritic joints at 12 and 24 h after the induction, providing evidence on the pathogenic roles of locally produced IL‐8 in MSU crystal-induced gouty arthritis.

  • 107
  • PDF
Changes in the proteins coating monosodium urate crystals during active and subsiding inflammation. Immunogold studies of synovial fluid from patients with gout and of fluid obtained using the rat subcutaneous air pouch model.
    E. Ortiz-BravoM. SieckH. Schumacher

    Biology, Medicine

    Arthritis and rheumatism

  • 1993

This study provides the first in vivo evidence supporting the notion derived from previous in vitro studies that proteins coating MSU crystals change as inflammation evolves, and may play an important role in the self-limited nature of gouty inflammation.

  • 109

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