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DOI:10.1186/s13075-015-0550-4 - Corpus ID: 8130059
@article{Pineda2015AnimalMO, title={Animal model of acute gout reproduces the inflammatory and ultrasonographic joint changes of human gout}, author={Carlos Pineda and Arturo Javier Fuentes-G{\'o}mez and Cristina Hern{\'a}ndez-D{\'i}az and Yessica Zamudio-Cuevas and Javier Fern{\'a}ndez-Torres and Ambar L{\'o}pez-Macay and I Alba-S{\'a}nchez and Javier Camacho-Galindo and Lucio Ventura and Luis Enrique G{\'o}mez-Quiroz and Mar{\'i}a Concepci{\'o}n Guti{\'e}rrez-Ru{\'i}z and Francisco J. Garc{\'i}a-v{\'a}zquez and Anthony M Reginato and Marwin Gutierrez and Alberto Gabriel L{\'o}pez-Reyes}, journal={Arthritis Research \& Therapy}, year={2015}, volume={17}, url={https://api.semanticscholar.org/CorpusID:8130059}}
- C. Pineda, A. J. Fuentes-Gómez, A. López-Reyes
- Published in 26 February 2015
- Medicine
The rabbit model of MSU crystal-induced acute arthritis efficiently reproduces the inflammatory, US, SF and histopathological changes of the human acute gouty attack.
35 Citations
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35 Citations
- HanLin XuShengping LiX. XueZiyi ChenY. Hua
- 2021
Medicine
BioMed research international
A minimally invasive method was developed to establish modified rat model of intra-articular MSU deposition and this model was proved to be a simple reproducible method to mimic the pathological characteristics of persistent gouty arthritis.
- Jiwei WangPeiqi Hao Tianrui Xu
- 2023
Medicine
RMD Open
The authors' model more accurately replicates the pathological features of gouty arthritis compared with gout induced by MSU crystal injections, making it particularly suitable for further investigations into the pathogenesis of gouts and also serves as a valuable platform for screening potential antigout agents.
- PDF
- HanLin XuShengkun LiX. XueZiyi ChenY. Hua
- 2020
Medicine
This model was proved to be a simple reproducible method to mimic the pathological characteristics of intra-articular crystal arthritis and suggested that the frequencies of MSU interventions promoted expression of proinflammatory factors.
- PDF
- E. NaredoJ. P. MedinaS. Pérez-BaosA. MedieroG. Herrero-BeaumontR. Largo
- 2018
Medicine
- 6
- W. BaoYi Xue C. Jia
- 2021
Medicine, Environmental Science
Wound repair and regeneration : official…
A novel gouty ulcer rat model was constructed, which also revealed the existence of persistent chronic inflammation, and MSU crystals were subcutaneously injected into the back of rats to simulate tophi formation and ulceration.
- 6
- J. P. MedinaIsmael Bermejo-Álvarez R. Largo
- 2023
Medicine
Frontiers in immunology
In vivo and in vitro results showed that a single systemic dose of Ad-MSC decrease the intensity and duration of the inflammatory response by an early local COX-2 upregulation and PGE2 release, and could be considered as a pharmacological alternative in patients with comorbidities that preclude conventional treatment.
- Hyosung KimHyun-Jeong HwangHan-Jun KimS. Do
- 2022
Medicine
Frontiers in Veterinary Science
The first report to confirm that articular gout can occur in dogs and cats is reported, confirmed by polarized microscopy.
- PDF
- Xiaoying LinTiejuan ShaoXianghui WenMingzhu WangChengping WenZhixing He
- 2020
Medicine
Advances in Rheumatology
Compared to hyperuricaemia model or acute gouts model, the compound gout model showed little advantages of elevating serum uric acid, causing foot swelling and gout inflammation, while it caused more severe serum inflammation and gut microbiota dysbiosis.
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- Ling CaoTianyi Zhao Xiaoxia Zhu
- 2021
Medicine
Journal of immunology research
HAG is an early performance of MSU crystal deposition in joints of gout and HUA, and early urate-lowering therapy (ULT) should be considered in patients with gout, DCS, or tophi.
- 19 [PDF]
- Yabin HuQing Yang Mi Yan
- 2018
Medicine
European Radiology
Following injection of MSU crystals, producing an acute gouty attack, CTP successfully assessed hemodynamic changes and the ascending rate of MVD was the highest among that of all parameters; so was the descending rate of CL.
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51 References
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There are no placebo-controlled, randomized clinical studies for any of the therapies commonly used, although comparative studies have demonstrated that many nonsteroidal anti-inflammatory drugs are equivalent to indomethacin with respect to controlling acute gouty attacks.
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Medicine
Annals of the rheumatic diseases
IL1 inhibition both prevented and relieved pain and ankle joint inflammation in response to intra-articular MSU crystals in mice, suggesting that IL1 Trap has the potential to both prevent and treat gouty arthritis.
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Medicine
Osteoarthritis and cartilage
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Medicine
In clinical practice they may be considered mainly for evaluating the presence and extent of crystal deposition, and structural changes that may impair function or functional outcomes, and also to monitor the response to urate-lowering therapy.
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- C. PinedaL. Amezcua-Guerra M. Gutierrez
- 2011
Medicine
These data demonstrate that morphostructural changes suggestive of gouty arthritis induced by chronic hyperuricemia frequently occur in both intra- and extra-articular structures of clinically asymptomatic individuals.
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Medicine
Ortopedia, traumatologia, rehabilitacja
The aim of this paper is to describe the ultrasonographic findings in rheumatologic pathology due to crystal deposition. There are four main types of crystals involved: monosodium urate, calcium…
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Medicine
Seminars in arthritis and rheumatism
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- E. NaredoJ. Uson E. Pascual
- 2014
Medicine
Annals of the rheumatic diseases
The results suggest that US bilateral assessment of one joint, three articular cartilages and two tendons may be valid for diagnosing gout with acceptable sensitivity and specificity.
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- A. NishimuraT. Akahoshi K. Matsushima
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Medicine
Journal of leukocyte biology
The intraarticular injection of a neutralizing anti‐IL‐8 antibody significantly attenuated the crystal‐induced joint swelling that occurred at 12 h, and neutrophil infiltration into arthritic joints at 12 and 24 h after the induction, providing evidence on the pathogenic roles of locally produced IL‐8 in MSU crystal-induced gouty arthritis.
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- 1993
Biology, Medicine
Arthritis and rheumatism
This study provides the first in vivo evidence supporting the notion derived from previous in vitro studies that proteins coating MSU crystals change as inflammation evolves, and may play an important role in the self-limited nature of gouty inflammation.
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