Albumin Globulin Ratio Calculator (A/G Ratio) - WOMS (2024)

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Interpretation: A/G Ratios of less than 1 are clinically significant, indicating that globulin proteins exceed the albumin protein."); container.find(".close-results").click(function() { container.find(".view .inner").show(); container.find(".results").hide(); }); } catch (error) { console.log(error) } }

The albumin globulin ratio calculator (A/G Ratio) determines how many albumin proteins are detectable in the blood relative to how many other proteins are present (globulins).

The percentage of albumin to globulin ought to be more than one. Medically relevant is a value less than one. Globulins are divided into four categories. They’re alpha 1, alpha 2, beta, and gamma, respectively.

Albumin and globulins make up the majority of the body’s essential proteins. Albumin is the body’s major carrier protein, with the largest amounts of any other protein. It likewise keeps oncotic pressure up, preventing blood from leaking out of the veins and arteries.

Albumin concentrations might be low due to insufficient synthesis of excessive turnover. Dehydration or any illness that causes a drop in plasma fluid might cause high amounts of albumin. The administration of albumin may also boost levels.

Albumin deficit is more symptomatic of long-term abnormality than of short-term abnormality.

Albumin Globulin Ratio Calculator: Method of computing A/G Ratio

This method is used to compute the albumin globulin ratio.

Albumin globulin ratio is calculated by dividing Albumin Level by Total Protein minus Albumin.

The ratio is the albumin level over the globulins level because globulins fill in the rest of the total protein which is not albumin.

The result of a normal ratio is higher than one. If the margin is less than 1, it means that the globulin proteins outnumber the albumin proteins, which is a medically important figure. This would necessitate a more thorough medical examination.

How To Use Albumin Globulin Ratio Calculator

The albumin globulin ratio calculator is easy to use. Just input the albumin level and total protein level, then press the “Calculate” icon. The albumin globulin ratio that results will thereafter be calculated and displayed instantly.

The albumin globulin ratio(calculated with the albumin globulin ratio calculator) helps determine whether or not a patient has liver or renal disease. Because albumin is synthesized in the liver, it could signal liver illness. Protein may be taken out in the urine if the kidneys are damaged, resulting in (high) albumin loss.

Various Types Of Albumin Globulin Tests

Various globulin diagnostics are performed. These are some of them:

Total protein test

This blood test evaluates globulin and albumin, two basic categories of proteins. If your protein levels are inadequate, you may be suffering from liver or renal illness.

Serum protein electrophoresis

This blood test examines gamma globulins and other substances in your blood. It may be utilized to detect a range of illnesses, such as immune system problems and myelodysplastic syndrome, a type of cancer.

Basics Of Albumin Globulin Ratio Calculator

Using albumin and total protein data, this albumin globulin ratio calculator determines the globulin ratio. Albumin accounts for almost half of the total protein in serum.

Proteins are essential building components for all cells and tissues, as well as for physical development, internal organ function, and overall health. Several organs are made up of them, and enzymes and hormones that govern physiological processes are made up of them.

The study determines the overall quantity of multiple types of proteins in the watery fraction of the blood (serum or plasma). Albumin and globulin are 2 types of proteins present in the bloodstream. Albumin accounts for around sixty percent of total protein.

Albumin is a protein synthesized by the liver that works as a transmission protein for numerous tiny molecules and ions, as well as a store of organic solutes for tissue metabolism and as the key element in regulating osmotic pressure (deterring liquid from trickling out of blood vessels).

The intravascular layer contains about thirty to forty percent of the individual’s overall albumin supply. The rest is extravascular and found in the intercellular fluid of the muscles and skin, mostly. In addition to sweat, tears, gastric juice, and bile, albumin can be detected in trace volumes in a plethora of human tissue secretions.

Perfectly preserved vascular endothelium doesn’t allow albumin to readily diffuse. As a result, it is the primary protein that controls the fluid movement and high-flow solutes via the capillaries by supplying the necessary colloid osmotic or oncotic pressure.

Albumin Globulin Ratio Calculator: Effect of Albumin

Albumin is responsible for seventy percent of the colloid osmotic pressure. It creates a better osmotic pressure than can be explained purely by the number of molecules immersed in plasma, and as a result, inert compounds like dextran cannot replicate it.

Albumin tends to draw and maintain cations, particularly Na+, in the vascular space because it has a negatively charged at normal blood ionic strength The Gibbs–Donnan effect is the name for this phenomenon.

Albumin also bonds a tiny number of Chlorine ions, which boosts its repulsive force and potential to keep Sodium ions in the capillary walls. Because of the increased osmotic pressure, the colloid osmotic pressure is fifty percent higher than it would be if protein content were the only factor.

Bilirubin, hormones, metals, vitamins, and medicines are all transported by albumin. It is vital in fat metabolism because it binds cholesterol and keeps it permeable in the blood. This is one of the reasons that hyperlipemia develops in hypoalbuminemia patients.

Albumin limits the number of active hormones present at each given period by bonding hormones. Albumin can also provide part of the anions required to control the plasma’s cations due to its negative charge.


The result is calculated using the albumin globulin ratio calculator, and it tells you how much albumin you have relative to how much globulin you have. The albumin globulin ratio is the name for the analysis. When your doctor discovers you have liver or kidney problems, the examination can help.

Protein levels may seem higher than they are if you are thirsty. Albumin levels may also arise as a result of dehydration. Before going to the doctor for a diagnosis, make sure you’ve drunk enough water. This will ensure an exact outcome.


What does the outcome of an albumin test imply?

Assessment outcomes may differ based on your age, sexual identity, medical records, test procedures, and other factors. It’s possible that the results of your tests don’t suggest a problem. Inquire about the consequences of your test results with your doctor.
Certain disorders cause your albumin level to drop while one or more types of globulins rise. Total protein levels should be between sixty and eighty grams/liter (g/L). Albumin levels should be between 35 and 52 g/L. The appropriate limit for globulins differs depending on the kind.
You could have the underlying liver disease if your protein levels drop. You could have stomach difficulties if your protein level is very high.
Low or high albumin globulin ratios can aid in the detection of various medical issues, such as various malignancies, autoimmune diseases, or congenital malformations.

What is the formula for calculating the albumin globulin ratio?

Because albumin is synthesized in the liver, it could signal liver illness. Protein may be washed out in the urine if the kidneys are damaged, resulting in (too much) albumin loss. This equation is used to compute the albumin globulin ratio.
Albumin Globulin Ratio = (Albumin Level)/(Total Protein – Albumin).

What does a globulin concentration of 4.0 indicate?

The typical globulin level is 2.0-3.9 g/dL (or 20-39 g/L). Variations in technology, procedures, and substances utilized cause some lab-to-lab variability. Globulin levels in the normal range often indicate a healthy balance of carrier proteins, enzymes, and antibodies, all of which are essential for numerous biological functions.

What does it mean to have a high globulin level?

The outbreak, inflammatory illness, or immunological problems can all be caused by high levels. High globulin levels can also signal cancers such as multiple myeloma, Hodgkin’s disease, and malignant lymphoma. Abnormal outcomes, on the other hand, could be caused by specific drugs, dehydration, or other circ*mstances.

Albumin Globulin Ratio Calculator (A/G Ratio) - WOMS (2024)


What is a normal Ag ratio level for a woman? ›

A ratio of 1.1–2.5 is considered normal. A ratio above 2.5 represents high albumin levels. Why do I need the globulin/AG ratio test? An AG ratio test is a sensitive test that helps physicians understand the body's ability to fight infections and maintain homeostasis.

Is a 2.4 A/G ratio bad? ›

A normal A/G ratio is between 1.1 and 2.5, although this can vary by lab. A low A/G ratio may be due to kidney disease, liver disease, chronic infections, type 2 diabetes, malnutrition, certain autoimmune diseases, and cancers.

How do you calculate albumin and globulin ratio? ›

To determine the A/G Ratio, the concentration of albumin and globulins in the blood is measured; subsequently, the A/G Ratio is calculated by dividing the albumin concentration by the globulin concentration. Fasting is typically required for this test.

Should I worry if my Ag ratio is low? ›

Low A/G ratio: This might be the sign an autoimmune disorder, where your body's immune system attacks healthy cells. It can also point to kidney disease or cirrhosis, which is inflammation and scarring of the liver. In some cases, a low A/G ratio can be a sign of a tumor in your bone marrow.

What is a good globulin level for a woman? ›

Normal value ranges are: Serum globulin: 2.0 to 3.5 grams per deciliter (g/dL) or 20 to 35 grams per liter (g/L)

What if ag ratio is slightly high? ›

High albumin concentration can be caused either by overproduction of albumin by the liver, or when fluid (serum) levels are too low. When a high A/G ratio is caused by high albumin levels, this can be due to severe dehydration or diarrhea, but can also occur during pregnancy .

What level of globulin is alarming? ›

Results more than 3.5 g/dL for globulin and more than 2.5 for an albumin/globulin ratio are considered high. But being on bed rest for too long, dehydration, and problems during the blood draw can also cause a high reading. Your healthcare provider will likely order additional tests.

How to improve ag ratio? ›

Taking Action for Optimal A/G Ratio

Nutrition: A balanced diet rich in nutrients supports both albumin and globulin synthesis. Adequate protein intake, along with a variety of vitamins and minerals, contributes to a healthy A/G ratio.

What is a normal protein level for a woman? ›

The normal range is 6.0 to 8.3 grams per deciliter (g/dL) or 60 to 83 g/L. Normal value ranges may vary slightly among different laboratories. Talk to your provider about the meaning of your specific test results. The examples above show the common measurements for results for these tests.

Is albumin globulin ratio important? ›

Low or high A/G ratios can help your healthcare providers identify other health problems, including certain cancers, autoimmune diseases, or some genetic disorders.

What is the albumin globulin ratio for fatty liver? ›

The Albumin/Globulin ratio in the total protein test will help assess the general health of the patient, and this index may suggest liver and kidney related diseases and assess liver function. . The albumin/globulin ratio in patients will usually be in the 1-1.5 range.

What are the symptoms of too much protein in your blood? ›

Common symptoms associated with High Blood Protein may include the following.
  • Fatigue and weakness.
  • Unexplained weight loss.
  • Swelling in the extremities.
  • Changes in urine colour or frequency.
  • Abdominal pain or discomfort.
  • Loss of appetite.
Jan 17, 2024

What autoimmune disease causes low ag ratio? ›

If your A/G ratio was low, it may be caused by:

An autoimmune disease, such as lupus. Liver disease, including cirrhosis.

Why would a doctor order an immunofixation test? ›

A serum immunofixation test measures specific proteins in your blood. It helps to identify certain illnesses that are otherwise hard to detect, such as multiple myeloma, a blood cancer. The test is also known as IFE, immunofixation electrophoresis, or protein electrophoresis.

What does it mean if albumin ratio is low? ›

Low albumin levels can be a sign of liver or kidney disease or another medical condition. High levels may be a sign of dehydration. Albumin is a protein made by your liver. Albumin enters your bloodstream and helps keep fluid from leaking out of your blood vessels into other tissues.

What is a high Ag ratio leukemia? ›

- A high albumin/globulin ratio suggests underproduction of immunoglobulins as may be seen in some genetic deficiencies and in some leukemias. - A high A/G ratio can be a sign of disease in your liver, kidney, or intestines. It's also linked to low thyroid activity and leukemia.

What is an alarming globulin level? ›

Results more than 3.5 g/dL for globulin and more than 2.5 for an albumin/globulin ratio are considered high. But being on bed rest for too long, dehydration, and problems during the blood draw can also cause a high reading. Your healthcare provider will likely order additional tests.

What is a normal albumin level for a woman? ›

Normal albumin levels in an adult's blood range from 3.5 to 5.5 grams per deciliter (g/dL). Lower-than-normal albumin levels in your blood (hypoalbuminemia) may indicate: Infection.

What is the Ag ratio in a liver function test? ›

The test also compares the amount of albumin in your blood to the amount of globulin. The comparison is called the albumin/globulin (A/G) ratio. If your total protein levels or A/G ratio results are not normal, it can be a sign of a serious health problem. Other names: total serum protein, TP albumin/globulin ratio.


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